Key result
Elevated serum irisin is positively linked to carotid intima-media thickness in adolescents with type 1 diabetes.
Why the study?
The role of irisin in adolescent type 1 diabetes patients and its relation to diabetes control and atherosclerosis was not well defined.
Are serum irisin levels associated with diabetes control and subclinical atherosclerosis in adolescents with type 1 diabetes?
Cross-Sectional (n=115)
No
Are serum irisin levels associated with diabetes control and subclinical atherosclerosis in adolescents with type 1 diabetes?
Effect estimate: r = 0.35
p-value: p=0.0001
Irisin levels are elevated in adolescent type 1 diabetes patients and correlate with poor glycemic control and early markers of subclinical atherosclerosis.
May mark glycemic control and atherosclerosis risk in adolescent T1D; hypothesis-generating, should not change practice.
AIM: The objective of this was to determine the role of irisin in adolescent type 1 diabetes (T1D) patients. METHODS: This study was conducted on 65 patients with T1D and 50 healthy individuals as control group. Serum irisin, glycosylated hemoglobin (HbA1c), lipid profile, oxidized low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio; carotid intimal medial thickness (cIMT), and aortic intimal medial thickness (aIMT) were evaluated for all participant. RESULTS: HbA1c, lipid profile, albumin/creatinine ratio, OxLDL, irisin, aIMT and cIMT were significantly higher in diabetic patients. Irisin had a positive correlation with age of diabetic patients, onset of diabetes, mid arm circumference, waist/height ratio, body mass index, HbA1c, and cIMT. CONCLUSION: Irisin is a marker for detection of diabetes control and early detection of subclinical atherosclerosis. Irisin had a relation with obesity.
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Dayem et al. (2020) conducted a cross-sectional in Type 1 Diabetes (n=115). Type 1 Diabetes vs. Healthy controls was evaluated on Correlation of serum irisin with carotid intimal medial thickness (cIMT) (r = 0.35, p=0.0001). Serum irisin levels were significantly elevated in adolescents with type 1 diabetes and positively correlated with carotid intimal medial thickness (r = 0.35, p = 0.0001) and HbA1c (r = 0.39, p = 0.0001).
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