Population
Renal wrap hypertensive rabbits and normotensive rabbits
Comparison
Assessment of hemodynamics at rest and after… vs Normotensive rabbits
Design
Preclinical
Authors
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Supports arteriolar remodeling as a driver of resistance in this model; leaves open translation to human hypertension and therapies.
Structural changes, specifically reduced lumen area in arterioles <200 microns, are sufficient to explain increased hemodynamic resistance in renal wrap hypertensive rabbits.
Neilson et al. (1993) studied this question.
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