Why the study?
Does vascular smooth muscle modulate viscoelasticity to filter high-frequency harmonics in the common carotid artery across different blood pressure states and ACE inhibitor treatment?
Does vascular smooth muscle modulate viscoelasticity to filter high-frequency harmonics in the common carotid artery across different blood pressure states and ACE inhibitor treatment?
This study evaluates the biomechanical filtering role of vascular smooth muscle in the carotid artery across normotensive, hypertensive, and ACE inhibitor-treated states.
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Supports potential carotid smooth muscle filtering across BP states; hypothesis-generating and should not yet change practice.
Reports on smart smooth muscle spring-dampers. Pulsatile pressure in arteries produces mechanical oscillations. High frequency vibrations tend to produce mechanical structure injures. Vascular smooth muscle (VSM) could react modulating viscoelasticity to protect the arterial wall, filtering the highest harmonics component present in the large and rapid slope of blood pressure. The aim of this study was to evaluate the filtering performance exerted by VSM in the human common carotid artery (CCA) in normotensive (NT, smart springdampers turned on), hypertensive (HT, smart spring-dampers in action) and angiotensin converting enzyme (ACE) inhibitors-treated hypertensive patients (HT-treated, smart spring-dampers tuned), and in harvested human CCA segments (smart spring-dampers turned off).
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Armentano et al. (2007) studied this question.
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