February 26, 2015Molecular EndocrinologyOpen Access

Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes

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Structured PICO

Population

Cardiomyocytes subjected to H2O2-induced oxidative stress

Intervention

Exendin-4 (GLP-1R stimulation)

Outcome

H2O2-induced reactive oxygen species production and synthesis of antioxidant enzymes (catalase, glutathione peroxidase-1, and manganese superoxide dismutase)surrogate

Epac plays a critical role in GLP-1R-mediated cardioprotection against oxidative stress and apoptosis in cardiomyocytes.

Discussion

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Implication

Epac-dependent GLP-1R effects may protect cardiomyocytes from oxidative stress; leaves open translation to human HF or ischemia.

Cite This Study

Mangmool et al. (2015) studied this question.

synapsesocial.com/papers/6a88f94a9f05dd9930a2ac44 https://doi.org/10.1210/me.2014-1346

Topics

Bremelanotide GLP-1 agonists cardiovascular outcomes

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Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes

Structured PICO

Discussion

Implication

Cite This Study

Topics

Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider