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Should not yet change practice in hypertension or renal disease; leaves open targeted pathway interventions.
The L-arginine-nitric oxide pathway appears to play an important role in systemic hypertension, progressive renal disease, nephrotoxicity (lead poisoning), inflammation and atherosclerosis. Interactions of nitric oxide with other systems (renin-angiotensin, endothelins, eicosanoids, cytokines and other regulators of inflammation) have been described. These interactions may be important in disease states.
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Saulo Klahr (1998) studied this question.
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