September 1, 2003AJP Cell Physiology

Increased phosphorylation of myosin light chain associated with slow-to-fast transition in rat soleus

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Population

Rats (soleus muscle)

Comparison

14 days of hindlimb suspension, 14 days of… vs Control (untreated) rats

Design

Preclinical

Follow-up

14 days

Authors

CBCyril BozzoUniversity of Padua LTL. TonioloUniversity of Verona YMYvonne MounierInstitut de Biologie de Lille

Discussion

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Implication

Hypothesis-generating for MLC2 in rodent muscle plasticity; leaves open translation to human cardiac or skeletal disease.

Structured PICO

Population

Rats (soleus muscle)

Intervention

14 days of hindlimb suspension (HS), 14 days of clenbuterol administration (CB), or 14 days of combined treatment (CB-HS)

Comparator

Control (untreated) rats

Outcome

Changes in myosin light chain (MLC)2 phosphorylation and isoform proportionssurrogate

In rat skeletal muscles, an increase of MLC2 phosphorylation is associated with the slow-to-fast transition regardless of whether hypertrophy or atrophy develops.

Cite This Study

Bozzo et al. (2003) studied this question.

synapsesocial.com/papers/6a88ff12185d41e08f75fd6f https://doi.org/10.1152/ajpcell.00441.2002

View Full Paper

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Increased phosphorylation of myosin light chain associated with slow-to-fast transition in rat soleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased phosphorylation of myosin light chain associated with slow-to-fast transition in rat soleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider