Translational Control of Poly(A)‐Binding Protein Expression

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Structured PICO

Population

in vitro transcribed PABP mRNA and a rabbit reticulocyte lysate cell-free system

Intervention

Removal of putative PABP-binding sites from the 5' UTR of PABP mRNA; addition of purified exogenous PABP

Comparator

Full-length PABP mRNA; absence of exogenous PABP

Outcome

Translation efficiency of PABP mRNA and binding of PABP to the 5' UTRsurrogate

PABP mRNA translation is repressed by a unique feed-back mechanism involving PABP binding to adenine-rich regions in its 5' UTR.

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Does not guide clinical practice; leaves open whether this feedback mechanism regulates cardiovascular protein synthesis in vivo.

Bag et al. (1996) studied this question.

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