Persistence, Up to 18 Months of Follow-Up, of Epirubicin-Induced Myocardial Dysfunction Detected Early by Serial Tissue Doppler Echocardiography: Correlation with Inflammatory and Oxidative Stress Markers

31 cancer patients with tumors at different sites scheduled to be treated with an epirubicin-based chemotherapy regimen, mean age 59 +/- 14 years, 8 males and 23 females.

Epirubicin-based chemotherapy regimen

Baseline (pre-treatment)

Early preclinical changes predictive of the risk for heart failure, including acute and late effects on left ventricular function measured by serial tissue Doppler echocardiography and inflammatory/oxidative stress markerssurrogate