Population
Single BK channels comprised of mixtures of functional subunits and subunits with a mutation to disrupt the…
Comparison
Varying the number of functional subunits (0 to 4) vs Channels with different numbers of functional…
Design
Preclinical
Authors
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These animal findings on BK channel gating should not change practice; extends mechanistic models of Ca2+ cooperativity but requires human validation.
Each BK channel subunit with a functional Ca-bowl contributes a stepwise increase to both the cooperativity of activation and the apparent Ca2+ affinity.
Niu et al. (2002) studied this question.
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