Key result
Hidden Markov model analysis of Shaker potassium channels revealed two subconductance levels rapidly traversed during most closing transitions, with maximal lifetimes of 52 and 22 μs at -100 mV.
Population
Shaker potassium channels (chimeric, high conductance, and normal conductance)
Comparison
Hidden Markov model analysis of deactivation… vs Recovery from N-type inactivation in Shaker…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of substates to mammalian cardiac Kv channel function.
Hidden Markov model analysis reveals that closing transitions of Shaker potassium channels involve intermediate subconductance states, suggesting stepwise conformational changes in individual subunits.
Zheng et al. (2001) studied Shaker potassium channels. Hidden Markov model analysis vs. Recovery from N-type inactivation was evaluated on Subconductance levels during closing transitions. Hidden Markov model analysis of Shaker potassium channels revealed two subconductance levels rapidly traversed during most closing transitions, with maximal lifetimes of 52 and 22 μs at -100 mV.
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