Population
Xenopus oocytes expressing mutant Shaker potassium channels
Comparison
Mutations of pore-region residue T442 vs Parental (unmutated) Shaker channels
Design
Preclinical
Authors
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These mutations inform basic K+ channel biophysics; leaves open mammalian or clinical relevance.
Mutations at the T442 pore-region residue in Shaker potassium channels drastically prolong open times and reveal intermediate subconductance states with altered ion selectivity.
Zheng et al. (1997) studied this question.
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