Population
Shaker K+ channel mutant (Sh-IR-T449V-I470C)
Comparison
Prolonged depolarizations (>50 ms, 1 min, 0 mV) vs Short depolarizations or Sh-IR background
Design
Preclinical
Authors
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Suggests slow inactivation yields a conductive state in mutant K+ channels; hypothesis-generating for native Kv gating in cardiac myocytes.
In the Shaker K+ channel mutant T449V-I470C, a new open state becomes progressively populated during long depolarizations, likely corresponding to a slow inactivated state that became conductive.
Olcese et al. (2001) studied this question.
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