Correlation between Charge Movement and Ionic Current during Slow Inactivation in Shaker K+ Channels
Population
Oocytes expressing mutant Shaker H4-Delta K+ channel and nonconducting mutant (Shaker H4-Delta-W434F)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports voltage-sensor role in Kv slow inactivation; leaves open translation to human cardiac electrophysiology.
Structured PICO
P
Population
Oocytes expressing mutant Shaker H4-Delta(6-46) K+ channel and nonconducting mutant (Shaker H4-Delta(6-46)-W434F)
I
Intervention
Prolonged depolarization
O
Outcome
Ionic and gating currents (voltage dependence of charge movement)surrogate
Prolonged depolarization modifies the conformation of the voltage sensor in Shaker K+ channels, a change associated with the process of slow inactivation.
Cite This Study
Olcese et al. (1997) studied this question.