Population
Shaker B K+ channels transiently expressed in Chinese hamster ovary (CHO) cells
Comparison
Mutations of amino acids in the pore and… vs Wild-type Shaker B K+ channel
Design
Preclinical
Authors
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Caution against clinical translation in cardiac electrophysiology; leaves open pore-gating mechanisms in human Kv channels.
Mutations in the pore structure of Shaker K+ channels alter closing and opening kinetics, indicating that gating mechanisms are influenced by pore occupancy and associated with separate molecular domains.
Molina et al. (1998) studied this question.
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