Population
Shaker potassium channel model
Design
Preclinical
Authors
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Does not support clinical translation; leaves open whether pore occupancy modulates C-type inactivation in human channels.
A decrease in potassium affinity at the internal ion binding site of the Shaker channel pore slows C-type inactivation by altering pore occupancy rather than the inactivation conformational change itself.
Ogielska et al. (1999) studied this question.
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