Why the study?
Does paxilline reduce the presence and duration of tonic-clonic seizures in animal models of chemically induced seizures?
Population
Animal models with seizures induced by intraperitoneal injection of picrotoxin or pentylenetetrazole
Comparison
Paxilline via intraperitoneal injection vs Saline
Design
Preclinical
Follow-up
24 hours following induction of initial seizure episode
Authors
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Paxilline shows anticonvulsant activity in rodent seizure models; leaves open translation of BK-channel blockade to human epilepsy.
Does paxilline reduce the presence and duration of tonic-clonic seizures in animal models of chemically induced seizures?
The BK-channel antagonist paxilline demonstrates significant anticonvulsant activity in animal models of chemically induced seizures.
Sheehan et al. (2008) studied this question.
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