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April 1, 2004Molecular Cancer TherapeuticsOpen Access

Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy

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Authors

ADAfshin DowlatiUniversity Hospitals of ClevelandDNDavid NetheryCase Western Reserve UniversityJKJeffrey A. KernNational Jewish Health

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Dowlati et al. (2004) studied this question.

synapsesocial.com/papers/6a89023d4f37e970fb7b3fdchttps://doi.org/10.1158/1535-7163.459.3.4
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin1996 · 169 citations
  2. 2Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins1993 · 199 citations
  3. 3Pharmacodynamic Studies of the Epidermal Growth Factor Receptor Inhibitor ZD1839 in Skin From Cancer Patients: Histopathologic and Molecular Consequences of Receptor Inhibition2002 · 256 citations