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SummaryColestipol, a high-molecular-weight polymer which binds bile acids, exerts a hypocholesteremic effect in several species. The addition of 1% colestipol to an atherogenic regimen (2% cholesterol, 6% corn oil) did not significantly affect serum or liver cholesterol levels of rabbits but did cause a significant reduction (p < .05) in atheromata in both the aortic arch and thoracic aorta. An appreciable number of rabbits fed 1% colestipol were free of atheromata.We are indebted to Dr. T. M. Parkinson of the Upjohn Co., Kalamazoo, MI for generously supplying the colestipol used in this work.
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Kritchevsky et al. (1973) studied this question.
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