Population
Neonatal rat cardiac fibroblasts isolated from 1- to 3-day-old Sprague-Dawley rats
Comparison
17 beta-estradiol (1 microM) and progesterone vs Untreated control cells (implied)
Design
Preclinical
Authors
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May inhibit neonatal rat fibroblast proliferation; hypothesis-generating for ovarian hormone effects on cardiac remodeling and requires human validation.
Ovarian hormones directly suppress DNA synthesis and upregulate extracellular matrix remodeling markers in neonatal rat cardiac fibroblasts, highlighting a potential mechanism for their cardiovascular effects.
Isabelle Le Mercier (2002) studied this question.
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