Why the study?
Does angiotensin II reduce infarct size and improve post-ischemic contractile dysfunction in isolated rat hearts subjected to ischemia-reperfusion injury?
Does angiotensin II reduce infarct size and improve post-ischemic contractile dysfunction in isolated rat hearts subjected to ischemia-reperfusion injury?
In an isolated rat heart model, angiotensin II reduces infarct size in a concentration-dependent manner but does not improve contractile stunning following ischemia-reperfusion injury.
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Angiotensin II may limit infarct size without alleviating stunning; leaves open translation to in vivo or clinical ischemia-reperfusion.
Ford et al. (2001) studied this question.
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