Why the study?
Does esmolol decrease the propofol blood concentration required to prevent response to command in healthy patients presenting for minor surgery?
Population
30 healthy patients presenting for minor surgery
Comparison
Esmolol bolus and then infusion (250 microg x kg… vs Placebo followed by target-controlled infusion…
Design
RCT, randomized, blinded observer
Follow-up
10 minutes of propofol infusion
Authors
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Esmolol does not reduce propofol requirements for loss of responsiveness; confirms no interaction on awakening threshold in healthy surgical patients.
Does esmolol decrease the propofol blood concentration required to prevent response to command in healthy patients presenting for minor surgery?
Esmolol does not affect the anesthetic requirement for loss of responsiveness during propofol anesthesia.
Orme et al. (2002) studied this question.
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