Why the study?
Autonomic nervous system dysregulation contributes to disease onset and progression, necessitating effective nonpharmacological methods for regulating autonomic function.
Sounds with inaudible high-frequency components may provide a nonpharmacological method to flexibly regulate autonomic nervous system activity based on situational demands.
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May support nonpharmacological ANS regulation via sound; hypothesis-generating and needs prospective confirmation before clinical consideration.
The dysregulation of the autonomic nervous system (ANS) activity notably contributes to the onset and progression of numerous diseases, including lifestyle-related and psychiatric disorders. This necessitates the development of effective nonpharmacological methods for regulating ANS function for therapeutic purposes and disease prevention. This study examined how the presence or absence of the inaudible high-frequency component (HFC) of sounds-which activates deep-brain structures-affects the ANS regulatory function. Under the N-back task condition, which requires concentration, exposure to sounds with HFC resulted in significantly higher sympathetic and parasympathetic nervous activities compared to sounds without HFC. Conversely, under the relaxation condition, the sounds with HFC significantly suppressed sympathetic nervous activity relative to sounds without HFC. Therefore, sounds with HFC may flexibly adjust the sympathetic and parasympathetic nervous activities based on situational demands.
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Jogasaki et al. (2025) studied this question.
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