Why the study?
Does sympathetic nerve stimulation induce the release of adenosine-like material from canine adipose tissue, and is it mediated by adrenergic alpha-receptors?
Population
Isolated perfused canine subcutaneous adipose tissue infused with 3H-adenine
Comparison
Sympathetic nerve stimulation vs Adrenergic alpha-receptor blockade during…
Design
Preclinical
Authors
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May implicate adenosine in alpha-adrenergic regulation of lipolysis; leaves open translation to human cardiometabolic disease.
Does sympathetic nerve stimulation induce the release of adenosine-like material from canine adipose tissue, and is it mediated by adrenergic alpha-receptors?
Sympathetic nerve stimulation releases adenosine or a related compound from canine subcutaneous adipose tissue via adrenergic alpha-receptor stimulation, potentially acting as a regulatory inhibitor of catecholamine-induced lipolysis.
Bertil B. Fredholm (1976) studied this question.
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