Calcium-Channel Antagonists Reduce Renal Protein Excretion

Letters15 January 1991Calcium-Channel Antagonists Reduce Renal Protein ExcretionRonald H. Lewis, MDRonald H. Lewis, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-2-167 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:In the brief report on the effects of diltiazem and lisinopril on the proteinuria associated with diabetes mellitus, Bakris (1) incorrectly implied that it was the first report of a calcium-channel antagonist affecting urinary protein excretion in humans. However, nicardipine has been shown to reduce the albumin excretion rate in hypertensive patients with type II diabetes mellitus. Baba and colleagues (2) compared the renal effects of an angiotensin converting enzyme inhibitor with those of enalapril and nicardipine in seven hypertensive patients with type II diabetes and microalbuminuria, using a randomized, crossover triaL Patients were treated for 4...References1. Bakris G. Effects of diltiazem or lisinopril on massive proteinuria associated with diabetes mellitus. Ann Intern Med. 1990;112:707-8. LinkGoogle Scholar2. BabaMurabayashiTakebe TSK. Comparison of the renal effects of angiotensin converting enzyme inhibitor and calcium antagonist in hypertensive type 2 (non-insulin-dependent) diabetic patients with microalbuminuria: a randomised controlled trial. Diabetologia. 1989;32:40-4. CrossrefMedlineGoogle Scholar3. StornelloValvoScapellato MEL. Hemodynamic, renal, and humoral effects of the calcium entry blocker nicardipine and converting enzyme inhibitor captopril in hypertensive type II diabetic patients with nephropathy. J Cardiovasc Pharmacol. 1989;14:851-5. CrossrefMedlineGoogle Scholar1. Bakris G. Effects of diltiazem or lisinopril on massive proteinuria associated with diabetes mellitus. Ann Intern Med. 1990;112:707-8. LinkGoogle Scholar2. BabaIshizakiMurabayashiAoyagiTamasawaTakebe TTSKNK. Multiple oral doses of nicardipine, a calcium-entry blocker: effects on renal function, plasma renin activity, and aldosterone concentration in mild-to-moderate essential hypertension. Clin Pharmacol Ther. 1987;42:232-9. CrossrefMedlineGoogle Scholar3. DemarieBakris BG. Effects of different calcium antagonists on proteinuria associated with diabetes mellitus. Ann Intern Med. 1990;113:987-8. LinkGoogle Scholar4. MickischSchmidMann OMJ. Calciumantagonisten bei chronischer Niereninsuffizienz. Dtsch Med Wschr. 1998;113:1546-8. CrossrefGoogle Scholar5. MimranInsuaRibsteinMonnierBringerMirouse AAJLJJ. Contrasting effects of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy. J Hypertens. 1988;6:919-23. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byScreening for Colorectal Cancer 15 January 1991Volume 114, Issue 2Page: 167-168KeywordsAlbuminsAngiotensin converting enzyme inhibitorDiabetes mellitusExcretionMicroalbuminuriaProteinsProteinuriaType 2 diabetes Issue Published: 15 January 1991 PDF downloadLoading ...