Angiotensin Converting Enzyme Inhibitors: The End of End-Stage Renal Disease?

Editorials15 September 1989Angiotensin Converting Enzyme Inhibitors: The End of End-Stage Renal Disease?Peter U. Feig, MD, Gale H. Rutan, MD, MPHPeter U. Feig, MDSearch for more papers by this author, Gale H. Rutan, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-451 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than 30 000 persons annually develop end-stage renal disease as a result of inexorably progressive renal insufficiency. Because of successful development and funding of maintenance therapy, over 120 000 patients live either on chronic dialysis or with renal allografts. The program has high morbidity and costs about $3 billion per year, that is, approximately $25 000 per patient. Further successes in prolonging life on maintenance therapy without affecting the rate of development of renal failure will result in further increases in this number, with the fastest growth among persons over age 65 (1). Arresting the progression of renal deterioration...References1. Eggers P. Effect of transplantation on the Medicare end-stage renal disease program. N Engl J Med. 1988;318:223-9. CrossrefMedlineGoogle Scholar2. KeaneAndersonAurellde ZeeuwNarinsPovar WSMDRG. Angiotensin converting enzyme inhibitors and progressive renal insufficiency. Current experience and future directions. Ann Intern Med. 1989;111:503-516. LinkGoogle Scholar3. AndersonBrenner SB. Role of intraglomerular hypertension in the initiation and progression of renal disease. In: Kaplan NM, Brenner BM, Laragh JH, eds. The Kidney in Hypertension, v 1. New York: Raven Press; 1987:67-76. Google Scholar4. Fine L. Preventing the progression of human renal disease: have rational therapeutic principles emerged? 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Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of Potassium MetabolismEnalapril reduces the albuminuria of patients with sickle cell diseaseLong-Term Beneficial Effects of Angiotensin-Converting Enzyme Inhibition in Patients With Nephrotic ProteinuriaDrug-Induced Renal DisordersContrasting effects of lisinopril and nifedipine on albuminuria and tubular transport functions in insulin dependent diabetics with nephropathyMolecular Biology of Human Renin and Its GeneInterventions in chronic renal failure.Angiotensin-Converting Enzyme Inhibitors and Renal Function 15 September 1989Volume 111, Issue 6Page: 451-453KeywordsAngiotensin converting enzyme inhibitorMedical dialysisMorbidityRenal failure Issue Published: 15 September 1989 PDF DownloadLoading ...