The design and synthesis of a series of natural product-like synthetic macrolides built upon a quinic acid-containing scaffold are described. Three of the macrolides ( 1, 3, and 6 ) have been shown to inhibit 4T1 breast cancer cell migration with low nanomolar to sub-micromolar IC 50 values (77, 525, and 550 nM, respectively) in complementary assays including a quantitative cell migration assay and a semiquantitative wound healing assay.
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Metaferia et al. (2007) studied this question.
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