Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells.

In a previous study, we reported a novel 14-membered ring macrolide, migrastatin isolated from culture broth of Streptomyces sp. MK929-43F1 as an inhibitor of tumor cell migration1). Recently, however, we found that our original migrastatin isolate contained teleocidin-related compounds which display strong inhibitory activity against tumor cell migration. In this report, we describe the effects of teleocidin-free migrastatin on tumor cell migration and on