Endothelial cells can modulate the production of a renin-like enzyme in vascular smooth muscle cells, highlighting local intercellular regulation.
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No immediate clinical implications from this animal model; leaves open endothelial modulation of vascular renin-like enzyme in vivo.
Cultured human vascular smooth muscle cells (VSMC) produced an immunologically specific renin-like enzyme. The production of the renin-like enzyme was increased by 1 mM N6-O2'-dibutyryladenosine 3',5' cyclic monophosphoric acid sodium salt (db-cAMP). When co-cultured with human vascular endothelial cells (EC) and human skin fibroblast (FB), the basal production of the renin-like enzyme was increased. And the extent of the increase by db-cAMP was amplified by co-culture with EC, but not by the co-culture with FB.
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Iwai et al. (1989) studied this question.
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