Why the study?
Does bisoprolol alter the percentage of maximal heart rate and heart rate reserve models for exercise prescription in healthy male subjects?
Population
10 healthy male subjects
Comparison
Bisoprolol 5 mg/day oral for 2 weeks vs Oral placebo for 2 weeks (crossover design)
Design
RCT, randomly received, double-blind
Follow-up
2 weeks
Authors
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Bisoprolol compromises standard %HRmax/%HRR exercise prescription; challenges conventional models and supports threshold-based alternatives.
Does bisoprolol alter the percentage of maximal heart rate and heart rate reserve models for exercise prescription in healthy male subjects?
Exercise prescription using standard %HRmax or %HRR methods has limited accuracy for patients taking beta-blockers, suggesting that aerobic and anaerobic thresholds or adjusted lower limits should be used instead.
Wonisch et al. (2003) studied this question.
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