Interactions of Calmodulin with Two Peptides Derived from the C-terminal Cytoplasmic Domain of the Cav1.2 Ca2+ Channel Provide Evidence for a Molecular Switch Involved in Ca2+-induced Inactivation

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Population

Synthetic peptides and fusion proteins derived from the Cav1.2 channel

Design

Preclinical

Authors

Discussion

Does not alter clinical Ca2+ channel management; leaves open whether this switch can be targeted in cardiac disease.

Population

Synthetic peptides and fusion proteins derived from the Cav1.2 channel

Intervention

Interaction with calmodulin at varying Ca2+ concentrations

Outcome

Interaction kinetics (Kd) and formation of ternary complexsurrogate

The CB and IQ motifs of the Cav1.2 channel interact with calmodulin to form a minimal molecular switch leading to Ca2+-induced inactivation.

Mouton et al. (2001) studied this question.

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