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July 20, 2000Human Gene Therapy

Pre-Existent Adenovirus Antibody Inhibits Systemic Toxicity and Antitumor Activity of CN706 in the Nude Mouse LNCaP Xenograft Model: Implications and Proposals for Human Therapy

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Authors

YCYu ChenGuangdong Academy of Medical SciencesDYDechao YuBioClinica (United States)DCD.E. CharltonSpirit AeroSystems (United Kingdom)

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Chen et al. (2000) studied this question.

synapsesocial.com/papers/6a891ef746f665d098760bc6https://doi.org/10.1089/10430340050083289
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Also Consider

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  1. 1The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors1997 · 416 citations
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  4. 4Impact of Preexisting and Induced Humoral and Cellular Immune Responses in an Adenovirus-Based Gene Therapy Phase I Clinical Trial for Localized Mesothelioma1998 · 200 citations