Population
Embryonic and neonatal cardiomyocytes from a novel titin-eGFP knockin mouse model
Design
Preclinical
Authors
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Calcium restricts titin mobility in animal sarcomeres; hypothesis-generating for activity-dependent filament stability, with no immediate clinical implications.
Titin is highly mobile within and between sarcomeres, and this mobility is primarily restricted by calcium, suggesting that fortification of the titin filament system is activity-dependent.
Lopes et al. (2011) studied this question.
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