Harnessing Nature’s Insights: Synthetic Small Molecules with Peroxidase‐Mimicking DNAzyme Properties

Substitute features: The demonstration that small DNAs can acquire enzymatic properties (DNAzyme activity) is appealing since it makes protein-based biotechnologies simpler. Herein, two further simplifications of this process are proposed: the substitution of DNAs for small molecules, called DOTA-templated synthetic G-quartets (DOTASQ), and of hemin for the more practically convenient iron(III) porphyrin (FeTPPS; see scheme).