Length-dependent potentiation and myosin light chain phosphorylation in rat gastrocnemius muscle

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Population

Rat gastrocnemius muscle

Comparison

In situ isometric contractile responses during… vs Resting conditions and comparison across…

Design

Preclinical

Authors

Discussion

Staircase potentiation length dependence appears independent of RLC phosphorylation; leaves open alternative mechanisms in mammalian skeletal muscle.

Population

Rat gastrocnemius muscle

Intervention

In situ isometric contractile responses during 10 s of repetitive stimulation at 10 Hz at optimal length (Lo), Lo - 10%, and Lo + 10%

Comparator

Resting conditions and comparison across different muscle lengths

Outcome

Degree of enhancement of developed tension (staircase potentiation) and myosin regulatory light chain (RLC) phosphorylationsurrogate

Length dependence of staircase potentiation in mammalian skeletal muscle may not be directly modulated by RLC phosphorylation.

Rassier et al. (1997) studied this question.

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Staircase potentiation length dependence appears independent of RLC phosphorylation; leaves open alternative mechanisms in mammalian skeletal muscle.