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May 1, 1990Journal of Cellular Physiology

Length‐dependence of isometric twitch tension potentiation and myosin phosphorylation in mouse skeletal muscle

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Population

Mouse extensor digitorum longus muscle

Comparison

Changes in muscle length and a 1.5 s tetanus vs Baseline quiescence and different muscle lengths

Design

Preclinical

Authors

RMRussell L. MoorfPennsylvania State UniversityAPAnthony PersechiniUniversity of Missouri–Kansas City

Discussion

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Overview

In mouse skeletal muscle, contraction-induced myosin P-light chain phosphorylation decreases with increased muscle length, while post-tetanic potentiation increases.

Structured PICO

P
Population
Mouse extensor digitorum longus muscle
I
Intervention
Changes in muscle length and a 1.5 s tetanus
C
Comparator
Baseline quiescence and different muscle lengths (e.g., L0 vs 1.2 L0 vs 1.23 L0)
O
Outcome
Post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylationsurrogate

In mouse skeletal muscle, contraction-induced myosin P-light chain phosphorylation decreases with increased muscle length, while post-tetanic potentiation increases.

Cite This Study

Moorf et al. (1990) studied this question.

synapsesocial.com/papers/6a8c17ee52e1a91077e9911ahttps://doi.org/10.1002/jcp.1041430209
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlated reduction of velocity of shortening and the rate of energy utilization in mouse fast-twitch muscle during a continuous tetanus.1983 · 67 citations
  2. 2The Time Course of the Active State in Relation to Sarcomere Length and Movement Studied in Single Skeletal Muscle Fibres of the Frog1971 · 96 citations
  3. 3Myosin light chain phosphorylation and tension potentiation in mouse skeletal muscle1989 · 84 citations
  4. 4Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. Implications for twitch potentiation in intact muscle.1989 · 293 citations
  5. 5Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle1982 · 172 citations