Why the study?
Does sodium dantrolene alter the relationship between PLC phosphate and isometric tension potentiation in mouse skeletal muscle?
Population
Intact mouse extensor digitorum longus muscles
Comparison
Sodium dantrolene vs Absence of sodium dantrolene
Design
Preclinical
Key result
Treatment of intact mouse skeletal muscle with sodium dantrolene produced a 73% reduction in isometric twitch tension and an approximately threefold increase in the slope of the PLC phosphate vs. ITP relationship.
Authors
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Temperature-dependent slope variation challenges Ca2+ sensitization hypothesis for PLC-mediated potentiation; leaves mechanism open in fast-twitch muscle.
Does sodium dantrolene alter the relationship between PLC phosphate and isometric tension potentiation in mouse skeletal muscle?
The findings support the hypothesis that isometric twitch tension potentiation in intact skeletal muscle is due to a PLC phosphorylation-induced sensitization of the contractile element to activation by Ca2+.
Palmer et al. (1989) studied Intact mouse extensor digitorum longus muscles. Sodium dantrolene vs. Absence of sodium dantrolene was evaluated on Isometric twitch tension and slope of the PLC phosphate vs. ITP relationship. Treatment of intact mouse skeletal muscle with sodium dantrolene produced a 73% reduction in isometric twitch tension and an approximately threefold increase in the slope of the PLC phosphate vs. ITP relationship.