Key result
Different-frequency conditioning stimuli increased the rate of force development in fatigued mouse skeletal muscle, which was strongly correlated with R-LC phosphorylation (r = 0.97, P < 0.001).
Population
Mouse extensor digitorum longus (EDL) muscle stimulated in vitro at 25 degrees C
Comparison
Different-frequency conditioning stimuli vs Without conditioning stimuli (rest)
Design
Preclinical
Authors
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Should not inform clinical fatigue management; leaves open whether R-LC phosphorylation modulates force recovery in human skeletal muscle.
Effect estimate: r = 0.97
p-value: p=< 0.001
Phosphorylation of myosin regulatory light chain increases the extent of twitch force development in fatigued mouse skeletal muscle.
Vandenboom et al. (1997) studied fatigued mouse skeletal muscle. different-frequency conditioning stimuli (CS) vs. without CS was evaluated on correlation between increased +dF/dtmax of potentiated twitches and R-LC phosphorylation (r = 0.97, p=< 0.001). Different-frequency conditioning stimuli increased the rate of force development in fatigued mouse skeletal muscle, which was strongly correlated with R-LC phosphorylation (r = 0.97, P < 0.001).
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