Why the study?
Does a 5-Hz 20-s conditioning stimulation increase peak isometric force and +dF/dtmax in mouse EDL muscles?
Population
Mouse extensor digitorum longus (EDL) muscles at 25 degrees C
Comparison
5-Hz 20-s conditioning stimulation vs Before application of the conditioning stimulation
Design
Preclinical
Authors
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Preclinical findings only; leaves open translation of frequency-dependent force potentiation to human muscle.
Does a 5-Hz 20-s conditioning stimulation increase peak isometric force and +dF/dtmax in mouse EDL muscles?
Myosin P-LC phosphorylation is associated with increased rate of force development at all frequencies, but force potentiation is limited to stimulation frequencies < 20 Hz in mouse EDL muscle.
Vandenboom et al. (1993) studied this question.
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