Why the study?
Does regulatory light chain phosphorylation increase eccentric contraction-induced injury in skinned fast-twitch skeletal muscle fibers?
Does regulatory light chain phosphorylation increase eccentric contraction-induced injury in skinned fast-twitch skeletal muscle fibers?
Regulatory light chain phosphorylation increases force deficits following eccentric contractions in fast-twitch skeletal muscle fibers, potentially by increasing the number of force-generating cross-bridges.
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Supports RLC phosphorylation in eccentric injury mechanisms; leaves open translation to intact muscle or clinical settings.
Childers et al. (2003) studied this question.
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