Key result
Changes in muscle length did not significantly affect tetanic or resting intracellular calcium, but calcium sensitivity was length-dependent in single fibres from mouse skeletal muscle.
Length-dependent changes in Ca2+ sensitivity of single muscle fibres are not simply related to variations in sarcomere length, suggesting roles for cross-bridge attachment or developed force.
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Length-dependent Ca²⁺ sensitivity in mouse skeletal fibers extends basic mechanisms; leaves open translation to human cardiac or in vivo function.
Balnave et al. (1996) studied this question. Muscle length changes vs. Optimum length (L(zero)) was evaluated on Myoplasmic free Ca2+ concentration and tetanic force production. Changes in muscle length did not significantly affect tetanic or resting intracellular calcium, but calcium sensitivity was length-dependent in single fibres from mouse skeletal muscle.
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