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May 5, 2005Journal of Experimental BiologyOpen Access

Contractile properties of mouse single muscle fibers, a comparison with amphibian muscle fibers

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Population

Single muscle fibers isolated from the flexor digitorum brevis muscle of the mouse

Comparison

Measurement of contractile properties vs Amphibian (frog) muscle fibers

Design

Preclinical

Authors

KEK. A. P. EdmanAstraZeneca (Sweden)

Discussion

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Implication

Species differences in tetanic rise caution against extrapolating mouse data to humans; leaves open mechanistic and translational questions for mammalian muscle.

Structured PICO

P
Population
Single muscle fibers (25-40 microm wide and 0.5-0.7 mm long) isolated from the flexor digitorum brevis muscle of the mouse
I
Intervention
Measurement of contractile properties (force and movement)
C
Comparator
Amphibian (frog) muscle fibers
O
Outcome
Maximum tetanic force and rising phase of the tetanussurrogate

Mouse single muscle fibers exhibit similar maximum tetanic force to frog fibers but have a significantly slower rising phase of tetanus.

Cite This Study

K. A. P. Edman (2005) studied this question.

synapsesocial.com/papers/6a7156e1660549caf2c5f802https://doi.org/10.1242/jeb.01573
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relation between sarcomere length and active tension in isolated semitendinosus fibres of the frog1966 · 129 citations
  2. 2FILAMENT LENGTHS IN STRIATED MUSCLE1963 · 336 citations
  3. 3Insulin‐like growth factor‐1 prevents age‐related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice2003 · 99 citations
  4. 4The sarcomere length‐tension relation determined in short segments of intact muscle fibres of the frog.1987 · 91 citations
  5. 5The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibres.1979 · 765 citations