Population
Single fast-twitch fibres from the extensor digitorum longus muscle of the rat and single twitch fibres from…
Comparison
Measurement of mechanics and energetics at short… vs Measurement at optimal sarcomere lengths
Design
Preclinical
Authors
Loading...
Indicates persistent cross-bridge cycling despite low force in skeletal muscle; leaves open translation to cardiac sarcomere function.
In skeletal muscle fibers, MgATPase activity and stiffness remain elevated at short sarcomere lengths despite near-zero isometric force, suggesting cross-bridge cycling continues with double actin filament overlap.
Stephenson et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: