March 1, 1988The Journal of General PhysiologyOpen Access

Muscle force and stiffness during activation and relaxation. Implications for the actomyosin ATPase.

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Population

Isolated skinned frog skeletal muscle fibers

Comparison

Altering biochemical species vs Physiological/normal levels of MgATP

Design

Preclinical

Authors

FBFrank V. BrozovichMayo Clinic in Arizona LYL. D. YatesOklahoma State University AGA. M. GordonAccra Technical University

Discussion

Member takes

Implication

Does not support clinical practice changes; leaves open the role of low-force cross-bridge states in cardiac performance in vivo.

Structured PICO

Population

Isolated skinned frog skeletal muscle fibers

Intervention

Altering biochemical species (lowering [MgATP] to 200 microM and elevating [H2PO4-] to 10 mM total Pi)

Comparator

Physiological/normal levels of MgATP

Outcome

Muscle force and stiffness during steady statesurrogate

The study suggests that the last cross-bridge state before dissociation could be an attached low-force or non-force-producing state, and cross-bridges are strongly bound to actin before Pi release.

Cite This Study

Brozovich et al. (1988) studied this question.

synapsesocial.com/papers/6a70b9fa31a3df824328fa43 https://doi.org/10.1085/jgp.91.3.399

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Muscle force and stiffness during activation and relaxation. Implications for the actomyosin ATPase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Muscle force and stiffness during activation and relaxation. Implications for the actomyosin ATPase.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider