Population
Single intact frog muscle fibres
Design
Preclinical
Authors
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Refines sarcomere structural models from animal data; leaves open translation to human cardiac mechanics or therapies.
The study demonstrates that the M3 reflection in active muscle originates mainly from myosin heads attached to actin, while the M6 reflection originates from a fixed structure in the myosin filament signaling length changes.
Brunello et al. (2006) studied this question.
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