November 1, 1999The Journal of PhysiologyOpen Access

Structural responses to the photolytic release of ATP in frog muscle fibres, observed by time‐resolved X‐ray diffraction

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Population

Single, permeabilised fibres of frog skeletal muscle at 5-6 C, with 10-20% of myosin cross-bridges…

Design

Preclinical

Authors

ATAndrey K. TsaturyanTel Aviv University SBSergey Y. BershitskyInstitute of Immunology and Physiology RBRonald BurnsNicolet Area Technical College

Discussion

Member takes

Implication

Supports myosin cross-bridge kinetics in skeletal muscle; leaves open translation to cardiac models or human physiology.

Structured PICO

Population

Single, permeabilised fibres of frog skeletal muscle at 5-6 C, with 10-20% of myosin cross-bridges cross-linked to thin filaments

Intervention

Photolytic release of ATP (0.33 or 1.1 mM) in the presence or absence of Ca2+

Outcome

Time courses of change in force, stiffness, and intensity of main equatorial reflections (1,0) and (1,1), third myosin layer line (M3), and first myosin-actin layer line (LL1)surrogate

The time course of structural changes in myosin cross-bridges closely mimics force development following ATP release in skeletal muscle fibers.

Cite This Study

Tsaturyan et al. (1999) studied this question.

synapsesocial.com/papers/6a727003ac440176ef2aac3c https://doi.org/10.1111/j.1469-7793.1999.00681.x

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Structural responses to the photolytic release of ATP in frog muscle fibres, observed by time‐resolved X‐ray diffraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural responses to the photolytic release of ATP in frog muscle fibres, observed by time‐resolved X‐ray diffraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider