February 1, 1988The Journal of General PhysiologyOpen Access

Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

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Population

Permeabilized guinea pig portal vein smooth muscle

Design

Preclinical

Authors

ASA V SomlyoUniversity of Virginia YGYale E. GoldmanHeart Failure / Cardiomyopathy TFT FujimoriUniversity of Pennsylvania

Discussion

Member takes

Implication

Indicates phosphorylation—not cross-bridges—limits force development in smooth muscle; leaves open translation to intact cardiovascular models.

Structured PICO

Population

Permeabilized guinea pig portal vein smooth muscle

Intervention

Laser-flash photolytic release of ATP from caged ATP [P3-1(2-nitrophenyl)ethyladenosine-5'-triphosphate]

Outcome

Stiffness and tension transientssurrogate

Light-chain phosphorylation, rather than intrinsic properties of actomyosin cross-bridges, limits the rate of force development in non-thiophosphorylated smooth muscles under physiological conditions.

Cite This Study

Somlyo et al. (1988) studied this question.

synapsesocial.com/papers/6a7027f653da1ffdb5079d7e https://doi.org/10.1085/jgp.91.2.165

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Implication

Indicates phosphorylation—not cross-bridges—limits force development in smooth muscle; leaves open translation to intact cardiovascular models.

Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider