January 1, 1999The Journal of PhysiologyOpen Access

Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres

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Population

Intact single muscle fibres of Rana temporaria (frog), 224 tetani from three fibres

Comparison

Isometric contraction and rapid shortening vs Resting muscle

Design

Preclinical

Authors

GPGabriella PiazzesiUniversity of Florence MRMassimo ReconditiUniversity of Florence IDIan M. DobbieMicron (United States)

Discussion

Member takes

Implication

Offers no direct clinical translation from frog skeletal muscle; extends basic models of myosin-force coupling.

Structured PICO

Population

Intact single muscle fibres of Rana temporaria (frog), 224 tetani from three fibres

Intervention

Isometric contraction and rapid shortening

Comparator

Resting muscle

Outcome

Changes in conformation of myosin heads measured by two-dimensional X-ray diffraction patternssurrogate

X-ray diffraction reveals that myosin head conformation changes synchronously with force development during isometric contraction in frog muscle fibers.

Cite This Study

Piazzesi et al. (1999) studied this question.

synapsesocial.com/papers/6a86da69c7caab105a154832 https://doi.org/10.1111/j.1469-7793.1999.305ae.x

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Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider