Population
Single fibres isolated from the anterior tibialis muscle of the frog Rana temporaria
Design
Preclinical
Authors
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No clinical implications; leaves open whether diffusible modulators drive force variation in human striated muscle.
The study demonstrates a twofold variation in normalized tetanic force in single frog muscle fibers, which correlates with energy liberation, suggesting modulation by diffusible substances.
Elzinga et al. (1989) studied this question.
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