Population
Frog single muscle fibres
Comparison
Twitch potentiators (Zn2+, tetraethylammonium… vs Control conditions (unpotentiated/normal [K+])
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether cross-bridge number governs length-tension relations in human myocardium.
This basic science study demonstrates that the shallow ascending limb of the sarcomere length-tension diagram in frog muscle fibers is likely caused by variations in the number of attached cross-bridges rather than internal opposing forces.
Julian et al. (1981) studied this question.
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