Why the study?
Do prophylactic intravenous antiemetics (ondansetron, droperidol, perphenazine, or metoclopramide) prevent severe emetic sequelae in patients undergoing total abdominal hysterectomy?
Population
360 ASA physical status I-III patients undergoing total abdominal hysterectomy (TAH)
Comparison
Intravenous ondansetron 4 mg, droperidol 1.25… vs Intravenous placebo prior to induction of…
Design
RCT, randomized, double-blind
Follow-up
postoperatively
Authors
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Supports prophylactic ondansetron, droperidol, or perphenazine after hysterectomy; confirms their RCT efficacy over placebo and metoclopramide.
Do prophylactic intravenous antiemetics (ondansetron, droperidol, perphenazine, or metoclopramide) prevent severe emetic sequelae in patients undergoing total abdominal hysterectomy?
Prophylactic intravenous perphenazine is effective and free of side effects for preventing postoperative nausea and vomiting after major gynecologic surgery.
Desilva et al. (1995) studied this question.
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